lipid microbubbles  (Lantheus Medical Imaging)

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of stable cavitation in insonated microbubbles. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked by the cyan dashed cuboid). b Quantification of the time-resolved radius (red solid line) and the wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line) of the microbubble. c Power spectrum of the time-resolved radius extracted from (b). d Angular distribution of microbubble radius at rest and at peak expansion over 10 cycles. e–h Quantification of the expansion ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{e}}$$\end{document} r e (e), the compression ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{c}}$$\end{document} r c (f), the oscillation asymmetry \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{a}}$$\end{document} r a (g), and maximum wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{mw}}$$\end{document} v mw (h) across 17 measured microbubbles. The red dotted curves in (e)–(g) were obtained by fitting the experimental data with a fourth-order polynomial. The red dotted curve in (h) was obtained by linear regression fitting

Article Snippet: To demonstrate COSDUM’s feasibility in a biologically relevant environment, we investigated the interaction between a stably oscillating microbubble and a nearby platelet in a suspension of microbubbles in whole blood (Charles River Laboratories, PB000F-2-KIT).

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of the collapse of an insonated microbubble. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked as the cyan dashed cuboid). b Quantification of the radial profile of the microbubble over time (red solid line) with its radial wall velocity profile \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line). c Radial power spectrum extracted from ( b )

Article Snippet: To demonstrate COSDUM’s feasibility in a biologically relevant environment, we investigated the interaction between a stably oscillating microbubble and a nearby platelet in a suspension of microbubbles in whole blood (Charles River Laboratories, PB000F-2-KIT).

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of microbubble-platelet interactions in whole blood. a Representative reconstructed frames showing the periodic motion of a platelet driven by an uncontacted microbubble. b Close-up view of the platelet during three representative oscillation cycles. c Quantification of the radial profile of the microbubble over time. d–e Central position of the platelet along the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$x$$\end{document} x - and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$y$$\end{document} y -axes, respectively

Article Snippet: To demonstrate COSDUM’s feasibility in a biologically relevant environment, we investigated the interaction between a stably oscillating microbubble and a nearby platelet in a suspension of microbubbles in whole blood (Charles River Laboratories, PB000F-2-KIT).

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of microbubble-red blood cell (RBC) interactions in whole blood. a Representative reconstructed frames showing the shape-adapted expansion of a microbubble around an adjacent RBC, resulting in a contact surface of approximately 25% of the RBC. b Microbubble radius as a function of angle and time. c 2D projected area of the microbubble over time, highlighting periodic oscillations and inter-cycle variations

Article Snippet: To demonstrate COSDUM’s feasibility in a biologically relevant environment, we investigated the interaction between a stably oscillating microbubble and a nearby platelet in a suspension of microbubbles in whole blood (Charles River Laboratories, PB000F-2-KIT).

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of stable cavitation in insonated microbubbles. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked by the cyan dashed cuboid). b Quantification of the time-resolved radius (red solid line) and the wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line) of the microbubble. c Power spectrum of the time-resolved radius extracted from (b). d Angular distribution of microbubble radius at rest and at peak expansion over 10 cycles. e–h Quantification of the expansion ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{e}}$$\end{document} r e (e), the compression ratio \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{c}}$$\end{document} r c (f), the oscillation asymmetry \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${r}_{\mathrm{a}}$$\end{document} r a (g), and maximum wall velocity \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{mw}}$$\end{document} v mw (h) across 17 measured microbubbles. The red dotted curves in (e)–(g) were obtained by fitting the experimental data with a fourth-order polynomial. The red dotted curve in (h) was obtained by linear regression fitting

Article Snippet: Encapsulated perfluoropropane microbubbles (Lantheus Medical Imaging, DefinityTM) were first diluted by adding one drop of the commercial microbubble suspension into a 1.5-mL microcentrifuge tube containing distilled water and were then gently mixed to ensure uniform dispersion.

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of the collapse of an insonated microbubble. a Time-resolved microbubble radial oscillations with representative frames showing microbubble dynamics in one ultrasound cycle (marked as the cyan dashed cuboid). b Quantification of the radial profile of the microbubble over time (red solid line) with its radial wall velocity profile \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$${v}_{\mathrm{w}}$$\end{document} v w (blue dotted line). c Radial power spectrum extracted from ( b )

Article Snippet: Encapsulated perfluoropropane microbubbles (Lantheus Medical Imaging, DefinityTM) were first diluted by adding one drop of the commercial microbubble suspension into a 1.5-mL microcentrifuge tube containing distilled water and were then gently mixed to ensure uniform dispersion.

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of microbubble-platelet interactions in whole blood. a Representative reconstructed frames showing the periodic motion of a platelet driven by an uncontacted microbubble. b Close-up view of the platelet during three representative oscillation cycles. c Quantification of the radial profile of the microbubble over time. d–e Central position of the platelet along the \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$x$$\end{document} x - and \documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$y$$\end{document} y -axes, respectively

Article Snippet: Encapsulated perfluoropropane microbubbles (Lantheus Medical Imaging, DefinityTM) were first diluted by adding one drop of the commercial microbubble suspension into a 1.5-mL microcentrifuge tube containing distilled water and were then gently mixed to ensure uniform dispersion.

Techniques:

Journal: Photonix

Article Title: Computational optical streak microscopy of megahertz acoustic microbubble dynamics

doi: 10.1186/s43074-026-00232-8

Figure Lengend Snippet: COSDUM of microbubble-red blood cell (RBC) interactions in whole blood. a Representative reconstructed frames showing the shape-adapted expansion of a microbubble around an adjacent RBC, resulting in a contact surface of approximately 25% of the RBC. b Microbubble radius as a function of angle and time. c 2D projected area of the microbubble over time, highlighting periodic oscillations and inter-cycle variations

Article Snippet: Encapsulated perfluoropropane microbubbles (Lantheus Medical Imaging, DefinityTM) were first diluted by adding one drop of the commercial microbubble suspension into a 1.5-mL microcentrifuge tube containing distilled water and were then gently mixed to ensure uniform dispersion.

Techniques:

Journal: Journal of Medical Primatology

Article Title: Comparison of Laser Doppler Flowmetry With Contrast‐Enhanced Ultrasound to Approximate Placental Microvascular Blood Flow in the African Green Monkey ( Chlorocebus aethiops sabaeus )

doi: 10.1111/jmp.70059

Figure Lengend Snippet: Microbubble‐based contrast‐enhanced ultrasound (CEUS). Schematic depiction of microbubble administration to enhance the microvasculature of the placenta that includes the intervillous spaces and spiral arteries. A transient increase in the mechanical index (MI) of the ultrasound results in microbubble destruction, followed by microbubble replenishment. Analysis was performed using MATLAB, with a region of interest drawn around the entire anterior placenta, as illustrated in the ultrasound image on the far left (red tracing). A time intensity curve was then generated and fit to a monoexponential model to allow for quantification of the microvascular flux rate ( β ). AF, amniotic fluid. Created in BioRender. Cilvik, S. (2026) https://BioRender.com/pg99ksd .

Article Snippet: We performed CEUS using the GE Logiq S8 equipped with a 5–12 MHz linear array probe (GE 11L) to evaluate regional two‐dimensional placental perfusion using the commercially‐available DEFINITY (R) microbubble contrast agent (Lantheus Medical Imaging), as described extensively in the rhesus macaque placenta [ , , , , , , , , ] and illustrated in Figure .

Techniques: Generated